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Development of Protocols to Optimize Insulin Treatment of Type 1 Diabetes in NOD Mice

✍ Scribed by Christian Grant; Shane Duclos; Catherine Moran-Paul; Lisa Spain; Guillermo Arreaza-Rubin; Dennis Guberski

Book ID
113541710
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
44 KB
Volume
135
Category
Article
ISSN
1090-2341

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Immunization with an insulin peptide–MHC
Immunization with an insulin peptide–MHC complex to prevent type 1 diabetes of NOD mice
✍ Li Zhang; Brian D. Stadinski; Aaron Michels; John W. Kappler; George S. Eisenbar πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 535 KB

## Abstract ## Background Mutating the insulin B:9–23 peptide prevents diabetes in NOD mice. Thus, the trimolecular complex of I‐A$^{\rm{g7}}$‐insulin B:9–23 peptide‐TCR may be essential for the development of spontaneous diabetes. Pathogenic T cells recognize the B:9–23 peptide presented by I‐A$^