Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

A possible linkage between AMP-activated

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

✍ Naoki Kimura; Chiharu Tokunaga; Sushila Dalal; Christine Richardson; Ken-ichi Y 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 374 KB

## Abstract **Background:** The mammalian target of rapamycin (mTOR) regulates multiple cellular functions including translation in response to nutrients, especially amino acids. AMP‐activated protein kinase (AMPK) modulates metabolism in response to energy demand by responding to changes in AMP.

A review of the preclinical and clinical

A review of the preclinical and clinical evidence for protein kinase C as a target for drug development for bipolar disorder

✍ Nancy DiazGranados; Carlos A. Zarate 📂 Article 📅 2008 🏛 Springer 🌐 English ⚖ 315 KB

Baker's yeast as a tool for the developm

Baker's yeast as a tool for the development of antifungal kinase inhibitors—targeting protein kinase C and the cell integrity pathway

✍ Jürgen J. Heinisch 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 681 KB

Today, the yeast Saccharomyces cerevisiae is probably the best-studied eukaryotic organism. This review first focusses on the signaling process which is mediated by the unique yeast protein kinase C (Pkc1p) and a downstream mitogen-activated protein kinase (MAPK) cascade. This pathway ensures cellul

Carnosol, a Dietary Diterpene, Displays

Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

✍ Johnson, Jeremy J. (author);Syed, Deeba N. (author);Heren, Chenelle R. (author); 📂 Article 📅 2008 🏛 Springer US 🌐 English ⚖ 817 KB

Carnosol, a Dietary Diterpene, Displays

Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

✍ Johnson, Jeremy J. (author);Syed, Deeba N. (author);Heren, Chenelle R. (author); 📂 Article 📅 2008 🏛 Springer US 🌐 English ⚖ 817 KB

Approaches and limitations of phosphatid

Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy

✍ Christina M. Coughlin; Daniel S. Johnston; Andrew Strahs; Michael E. Burczynski; 📂 Article 📅 2010 🏛 Springer US 🌐 English ⚖ 607 KB