The need to get a tool for biological parameters estimation of new compounds for clinical applications, supports the postulation of predictive models as an alternative to conventional classical assays being no necessary the use of experimentation in animals. Our main aim in this work is to determine
Development of predictive retention–activity models of butyrophenones by biopartitioning micellar chromatography
✍ Scribed by Y. Martín-Biosca; M. Molero-Monfort; S. Sagrado; R. M. Villanueva-Camañas; M. J. Medina-Hernández
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 150 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0269-3879
- DOI
- 10.1002/bmc.77
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The predictive and interpretative capability of quantitative chromatographic retention-biological activity models is supported by the fact that in adequate experimental conditions the solute partitioning into the chromatographic system can emulate the solute partitioning into lipid bilayers of biolo
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