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Development of porous apatite ceramic for local delivery of chemotherapeutic agents

✍ Scribed by Itokazu, Mansho ;Sugiyama, Tadashi ;Ohno, Takatoshi ;Wada, Eiji ;Katagiri, Yoshihiro

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 63 KB
Volume: 39
Category: Article
ISSN: 0021-9304
DOI: 10.1002/(sici)1097-4636(19980315)39:4<536::aid-jbm5>3.0.co;2-k

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✦ Synopsis

An experimental study was conducted on a drug delivery system (DDS), using porous apatite ceramics (PAC): hydroxyapatite block (HAb) [Ca 10 (PO 4 ) 6 (OH) 2 ] having a porosity of 35-48% and pore size range of 50-300 m, and ␤-tricalcium phosphate block (TCP) [Ca 3 (PO 4 ) 2 ] having a porosity of 75-80% and pore size range of 100-400 m, for sustained release of a chemotherapeutic agent. Methotrexate (MTX) was loaded in the pores of PAC blocks by centrifuging the blocks in MTX solution. Impregnation of MTX in PAC blocks (1 cm 3 ) was confirmed by a magnetic resonance imaging (MRI) study using Gadolinium-DTPA enhancement. The MRI showed high signal intensity in the PAC, which was confirmed by dye loading into the pores. To estimate the MTX-releasing capability of the PAC, the blocks were stored in 3 mL of phosphate-buffered saline (PBS) at 37°C and the PBS was replaced every 48 h. The amount of MTX released was assayed by high-performance liquid chromatography. This study showed that MTX-impregnated PAC (0.63-2.25 mg/block) released the drug in a steady manner and maintained its concentration (0.1-1.0 g/mL) up to 12 days. This concentration is high enough to be effective against tumor cells. Chemotherapeutic agentimpregnated PAC, prepared by simple centrifugation, could be a valuable form of local chemotherapy when used as a strut graft to repair bone defects. This new DDS material could also be used as an adjuvant to extended curettage and provide a means to reduce the recurrence of tumors without risk of systemic toxicity.

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