Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing acetazolamide are reviewed. Acetazolamide's solubility and permeability characteristics according to the Biopharmaceutics Cl
Development of oral liquid dosage forms of acetazolamide
β Scribed by Jagdish Parasrampuria; V. Das Gupta
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 273 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0022-3549
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## Abstract A high performance liquid chromatographic assay for the quantitation of acetazolamide in both tablet and injection form is described. Acetazolamide is extracted with 0.005 M NaOH solution containing 0.3 mg/mL sulphadiazine (internal standard).A commercially available ΞΌβBondapak C~18~ ca
Predictive scientific principles and methods to assess in vivo performance of pharmaceutical dosage forms based on in vitro studies are important in order to minimize costly animal and human experiments during drug development. Because of issues related to poor solubility and low permeability of new