A novel synthetic route to 7-substituted
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Edward C. Taylor; Bin Liu
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Article
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1999
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Elsevier Science
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French
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This paper describes a further synthesis of the pyrrolo [2,3-d]pyrimidine antitumor agent MTA (LY231514). Manganie triacetate dihydrate-induced radical cyclization of methyl N-crotyl-N-(3',4'dimethoxybenzyl)malonamide (4d) yielded the 3-carbomethoxy-2-pyrrolidinone 5d that was then thiated with P2S5