Development of LBP110 expression by neural crest-derived enteric precursors: Migration and differentiation potential inls/ls mutant mice
✍ Scribed by Howard, Marthe J. ;Gershon, Michael D.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 836 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-3034
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✦ Synopsis
Neural crest-derived cells acquire a neurofilament protein were located along the entire 110-kD laminin-binding protein (LBP110) when they extent of the bowel up to but not including the termicolonize the murine bowel. Laminin stimulates nal colon. By E16, both the proximal and terminal LBP110-expressing cells to develop as neurons. We colon contained cells expressing LBP110 and neurohave followed the development of LBP110 by neural filaments. The pattern of immunoreactivity could not crest-derived cells as they enter the gut of control and be distinguished between ls/ls and control animals ls/ls mutant mice. The expression of neurofilament prior to E16. By E16, when the terminal colon of conand choline acetyltransferase was used as markers of trol animals contained many cells expressing LBP110 a neuronal phenotype. Tyrosine hydroxylase was used and neurofilaments, the terminal colon of ls/ls animals as a marker for the mash-1-dependent lineage of enlacked cells expressing these proteins; nevertheless, teric precursors, while calcitonin gene-related peptide structures outside of the terminal colon were heavily was used as a marker for the mash-1-independent endowed with cells expressing LBP110 and neurofillineage of crest-derived cells. A subset of cells expressaments. These ectopically located cells derived from ing LBP110 was located along the vagi at E10 at cerviboth mash-1-dependent and -independent lineages cal and thoracic levels. At E12, cells expressing of crest-derived precursors. ᭧ 1998 John Wiley & Sons, Inc. LBP110 extended from the foregut to the midgut. The