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Development of hypoxia-inducible factor (HIF)-1α inhibitors: Effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia

✍ Scribed by Nakamura, Hiroyuki; Yasui, Yuka; Maruyama, Minako; Minegishi, Hidemitsu; Ban, Hyun Seung; Sato, Shinichi

Book ID
120393846
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
645 KB
Volume
23
Category
Article
ISSN
0960-894X

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## Abstract At the cellular level hypoxia induces transcriptional response that is mediated by the transcription factor hypoxia‐inducible factor (HIF). HIF is regulated at the level of its α subunit by 2‐oxoglutarate (2OG)‐dependent oxygenases that hydroxylate specific prolyl and asparaginyl residu