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Development of hypertension in neuroblastoma during therapy: A case report

✍ Scribed by Wolff, Johannes E. A. ;Bauch, Hans Jochen ;Roessner, Albert ;Boos, Joachim ;Gressner-Brocks, Veronika ;Ritter, Jörg ;Jürgens, Herbert

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
824 KB
Volume
21
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

A case of stage 4 neuroblastoma that developed excessive hypertension on day 120 of chemotherapy is presented. The tumor initially had responded well to chemotherapy; however, while the tumor mass decreased, plasma and urine catecholamines and the blood pressure increased. The plasma concentrations of noradrenaline, adrenaline, and dopamine increased to 26.4, 1.8, and 36.2 μg/l, respectively. The profile of catecholamine metabolites changed: on day 150 of therapy, noradrenaline, adrenaline, and dopamine levels were increased, whereas HVA and VMA levels were decreased when compared to day 1 of therapy. The only residual neuroblastoma tissue visible on MIBG scintigraphy on day 150 of treatment was a metastasis in the left tibia which was irradiated with 24 Gy. The adrenaline concentration in the left femoral vein was twice as high compared to the right femoral vein. A treatment, possibly radiation‐associated tumor cell alteration resulting in a different catecholamine production, is discussed. © 1993 Wiley‐Liss, Inc.

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