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Development of Hybrid Models for Metabolic Control Analysis of the Central Carbon Metabolism of Escherichia coli

✍ Scribed by E. Franco-Lara; J. Hiller; H. Link; D. Weuster-Botz

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
56 KB
Volume
76
Category
Article
ISSN
0009-286X

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✦ Synopsis

optischen Sensoren in Schüttelkolben, Reagenzglasreaktoren und Mikrotiterplatten der Firma Presens GmbH in Regensburg [1]. In diesen Satzverfahren sind nun die Umweltparameter nicht mehr konstant, und es wird kein stationärer Zustand erreicht. Dabei wird der stationäre Zustand für intrazelluläre Metabolite nur annäherungsweise erreicht. Trotzdem ist der Vergleich metabolischer Flüsse beim Einsatz von verschiedenen Substraten oder Mutanten gut möglich, wenn bestimmte Randbedingungen berücksichtigt werden. Am Beispiel von Corynebacterium glutamicum, das zu Synthese von Lysin eingesetzt wird, wird gezeigt, wie solche vergleichende Untersuchungen durchgeführt werden können und zu neuen Vorschlägen für das Stammdesign führen [2].

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