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Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps

✍ Scribed by George Loizou; Martin Spendiff; Hugh A. Barton; Jos Bessems; Frédéric Y. Bois; Michel Bouvier d’Yvoire; Harrie Buist; Harvey J. Clewell III; Bette Meek; Ursula Gundert-Remy; Gerhard Goerlitz; Walter Schmitt

Book ID
113965304
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
196 KB
Volume
50
Category
Article
ISSN
0273-2300

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Evaluation of physiologically based pharmacokinetic models for use in risk assessment
✍ Weihsueh A. Chiu; Hugh A. Barton; Robert S. DeWoskin; Paul Schlosser; Chad M. Th 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

## Abstract Physiologically based pharmacokinetic (PBPK) models are sophisticated dosimetry models that offer great flexibility in modeling exposure scenarios for which there are limited data. This is particularly of relevance to assessing human exposure to environmental toxicants, which often requ