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Development of freeze-dried biosynthetic Factor VIII: I. A case study in the optimization of formulation

✍ Scribed by Jameel, Feroz; Tchessalov, Serguei; Bjornson, Erik; Lu, Xiaofeng; Besman, Marc; Pikal, Michael


Book ID
120653588
Publisher
Informa plc
Year
2009
Tongue
English
Weight
965 KB
Volume
14
Category
Article
ISSN
1083-7450

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Phase separation in amorphous freeze-dried proteins systems is speculated to occur, but limitations in methods of detection have hindered progress in identifying and studying this phenomenon. We present here preliminary results obtained on model two-component protein-stabilizer systems that illustra