Gene-directed enzyme prodrug therapy for
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Rosetta Martiniello-Wilks; Allison Dane; Dale J. Voeks; Geetha Jeyakumar; Elin M
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Article
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2004
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John Wiley and Sons
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English
β 310 KB
π 1 views
## Abstract ## Background Geneβdirected enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar