Development of Electroactive and Elastic Nanofibers that contain Polyaniline and Poly(L-lactide-co-ε-caprolactone) for the Control of Cell Adhesion
✍ Scribed by Sung In Jeong; In Dong Jun; Moon Jae Choi; Young Chang Nho; Young Moo Lee; Heungsoo Shin
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 380 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
In this work, electrically conductive polyaniline (PAni) doped with camphorsulfonic acid (CPSA) is blended with poly(L‐lactide‐co‐ε‐caprolactone) (PLCL), and then electrospun to prepare uniform nanofibers. The CPSA‐PAni/PLCL nanofibers show a smooth fiber structure without coarse lumps or beads and consistent fiber diameters (which range from 100 to 700 nm) even with an increase in the amount of CPSA‐PAni (from 0 to 30 wt.‐%). However, the elongation at break decreases from 391.54 ± 9.20% to 207.85 ± 6.74% when 30% of CPSA‐PAni is incorporated. Analysis of the surface of the nanofibers demonstrates the presence of homogeneously blended CPSA‐PAni. Most importantly, a four‐point probe analysis reveals that electrical properties are maintained in the nanofibers where the conductivity is significantly increased from 0.0015 to 0.0138 S · cm^−1^ when the nanofibers are prepared with 30% CPSA‐PAni. The cell adhesion tests using human dermal fibroblasts, NIH‐3T3 fibroblasts, and C2C12 myoblasts demonstrate significantly higher adhesion on the CPSA‐PAni/PLCL nanofibers than pure PLCL nanofibers. In addition, the growth of NIH‐3T3 fibroblasts is enhanced under the stimulation of various direct current flows. The CPSA‐PAni/PLCL nanofibers with electrically conductive properties may potentially be used as a platform substrate to study the effect of electrical signals on cell activities and to direct desirable cell function for tissue engineering applications.
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