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Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound

✍ Scribed by Shimamura, M; Sato, N; Taniyama, Y; Yamamoto, S; Endoh, M; Kurinami, H; Aoki, M; Ogihara, T; Kaneda, Y; Morishita, R

Book ID: 110039610
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 366 KB
Volume: 11
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3302323

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Background Although gene therapy might become a promising approach to treat spinal cord injury, the safety issue is a serious consideration in human gene therapy. Plasmid DNA transfer is safer than viral vectors, but the transfection efficiency is quite low. To overcome the problem, we applied the u