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Development of chiral molecular crystals

โœ Scribed by Sara J. Krivickas; Chiho Hashimoto; Kazuyuki Takahashi; John D. Wallis; Hatsumi Mori


Book ID
112182467
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
850 KB
Volume
9
Category
Article
ISSN
1862-6351

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Chiral compounds, N-methyl-, N-ethyl-, and N-n-propylcholamides, form crystalline inclusion compounds with water or small organic substances. The compounds were analyzed by X-ray diffraction methods. It was found that the crystals have bilayered structures accumulated by chiral molecular sheets. The

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The lattice energies of a number of chiral drugs with known crystal structures were calculated using Dreiding II force ยฎeld. The lattice energies, including van der Waals, Coulombic, and hydrogen-bonding energies, of homochiral and racemic crystals of some ephedrine derivatives and of several other

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Molecular mechanics calculations, using the AMBER program (version 3.0), are presented on the radiogenic electron-capture radical formation in the crystalline chiral organophosphorus compounds (2R,4S,5R) and (2S,4S,5R) 2-chloro-3,4-dimethyl-5-phenylphospholidine 2-sulfide (respectively 1 and 2). Geo