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Development of Catalytic Asymmetric 1,4-Addition and [3 + 2] Cycloaddition Reactions Using Chiral Calcium Complexes

✍ Scribed by Tsubogo, Tetsu; Saito, Susumu; Seki, Kazutaka; Yamashita, Yasuhiro; Kobayashi, Shu̅


Book ID
115481002
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
445 KB
Volume
130
Category
Article
ISSN
0002-7863

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The synthesis and resolution of cis-1-amino-2-hydroxy-1,2,3,4tetrahydronaphthalene 5 by a simple and straightforward methodology has been achieved. The homochiral aminoalcohol has been used in the catalytic reduction of ketones by means of BH 3 .SMe2 affording secondary alcohols in high enantiomeric