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Development of binuclearity and DNA-polyploidization in the growing mouse liver

✍ Scribed by N. Böhm; N. Noltemeyer

Publisher
Springer
Year
1981
Tongue
English
Weight
407 KB
Volume
72
Category
Article
ISSN
1432-119X

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## Abstract The utility of liver H‐__ras__ codon 61 CAA to AAA mutant fraction as a biomarker of liver tumor development was investigated using neonatal male mice treated with 4‐aminobiphenyl (4‐ABP). Treatment with 0.1, 0.3, or 1.0 μmol 4‐ABP produced dose‐dependent increases in liver DNA adducts