Development of autoimmunity to transglutaminase C in children of patients with type 1 diabetes: relationship to islet autoantibodies and infant feeding
β Scribed by S. Hummel; M. Hummel; J. Banholzer; D. Hanak; U. Mollenhauer; E. Bonifacio; A. G. Ziegler
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 113 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0012-186X
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To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibo
Factors associated with diabetes onset were analysed for their predictive value in 708 first-degree relatives of Type 1 (insulin-dependent) diabetic patients including 374 parents and 308 siblings of Type i diabetic patients. Relatives were prospectively followed for 2 304 subject years with blood s