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Development of an oral formulation for ICAM-1 antisense oligonucleotides

โœ Scribed by S.M Stepkowski; W Chen; R Geary; M.E Wang; T Condon; K Stecker; C.F Bennett

Book ID
117230837
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
58 KB
Volume
33
Category
Article
ISSN
0041-1345

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In vivo study was performed to determine the tolerability and pharmacokinetics of ISIS 104838, a phosphorothioate antisense oligonucleotide targetting human tumour necrosis factor alpha (TNF-a) mRNA, following multi-dose administration via intravenous and oral routes. Oral tablet formulations of ISI