Development of an optimal antigen retrieval protocol for immunohistochemistry of retinoblastoma protein (pRB) in formalin fixed, paraffin sections based on comparison of different methods

DEVELOPMENT OF AN OPTIMAL PROTOCOL FOR A

DEVELOPMENT OF AN OPTIMAL PROTOCOL FOR ANTIGEN RETRIEVAL: A ‘TEST BATTERY’ APPROACH EXEMPLIFIED WITH REFERENCE TO THE STAINING OF RETINOBLASTOMA PROTEIN (pRB) IN FORMALIN-FIXED PARAFFIN SECTIONS

✍ SHI, SHAN-RONG; COTE, RICHARD J.; YANG, CHRISTINA; CHEN, CHEN; XU, HONG-JI; BENE 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 912 KB

The retinoblastoma (RB) gene, which encodes the nuclear RB protein (pRB), is believed to be involved in cell cycle control and cell differentiation. Studies have demonstrated that loss of RB function may play a role in tumour formation and progression of a variety of human turnours, such as bladder,