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Development of an oncolytic herpes simplex virus using a tumor-specific HIF-responsive promoter

✍ Scribed by Longo, S L; Griffith, C; Glass, A; Shillitoe, E J; Post, D E


Book ID
109842753
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
854 KB
Volume
18
Category
Article
ISSN
0929-1903

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## Abstract Two technical hurdles, gene delivery and target specificity, have hindered the development of effective cancer gene therapies. In order to circumvent the problem of tumor specificity, the suicide gene, HSV‐1 thymidine kinase (HSV‐Tk), was modified with a complex 5β€² upstream‐untranslated