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Development of an Efficient and Straightforward Methodology Toward the Synthesis of Molecularly Diverse 2,6-Disubstituted 3,4-Dihydropyrimidin-4(3H)-ones.

✍ Scribed by David Font; Montserrat Heras; Jose M. Villalgordo

Publisher: John Wiley and Sons
Year: 2003
Weight: 241 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200301151

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## Abstract Fluoroboric acid supported on silica gel (HBF~4~‐SiO~2~) catalyzes efficiently the three component condensation of an aldehyde, a 1,3‐dicarbonyl compound and urea or thiourea to afford the corresponding 3,4‐dihydropyrimidin‐ 2(1__H__)‐ones and thiones in high yields. The ambient conditi