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Development of adenocarcinomas after transplantation of rat glandular stomachs treated in vitro with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)

✍ Scribed by Y. Kurokawa; M. Takahashi; Y. Hayashi; Y. Ohno; N. Takamura


Publisher
Springer
Year
1983
Tongue
English
Weight
831 KB
Volume
39
Category
Article
ISSN
1420-682X

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␤-Propiolactone (BPL) and N-methyl-NЈ-nitro-N-nitrosoguanidine (MNNG) are two direct alkylating agents that induce multiple genetic lesions and tumors in the rodent stomach. We measured the kinetics of the induction of DNA damage by using the single-cell gel electrophoresis assay (SCGE) and the indu