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Development of acute myeloid leukemia associated with Ph-negative clone with inv(3)(q21q26) during imatinib therapy for chronic myeloid leukemia

✍ Scribed by Pavel Dvorak; Martina Hruba; Ivan Subrt


Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
288 KB
Volume
33
Category
Article
ISSN
0145-2126

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## Abstract Imatinib mesylate (IM) is the standard first‐line treatment for patients with chronic myeloid leukemia (CML). Surprisingly, 2–15% of patients achieving a complete cytogenetic response develop cytogenetic abnormalities in Philadelphia (Ph)‐negative cells. Following hematopoietic stem cel