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Development of a Whole Body Physiologically Based Model to Characterise the Pharmacokinetics of Benzodiazepines. 1: Estimation of Rat Tissue-Plasma Partition Ratios

โœ Scribed by Ivelina Gueorguieva, Ivan A. Nestorov, Susan Murby, Sophie Gisbert, Brent Collins, Kelly Dickens, Judith Duffy, Ziad Hussain, Malcolm Rowland


Book ID
119651586
Publisher
Springer
Year
2004
Tongue
English
Weight
333 KB
Volume
31
Category
Article
ISSN
1573-8744

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A priori prediction of tissue:plasma par
โœ Patrick Poulin; Frank-Peter Theil ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 374 KB ๐Ÿ‘ 3 views

The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib