✦ LIBER ✦

Development of a transmucosal technique for erythromycin delivery to treat gastroparesis

✍ Scribed by Ryan McLemore; Brian Lunt; Sarah Salameh; John K. DiBaise; Michael D. Crowell; Brent L. Vernon

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 217 KB
Volume: 99
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.22037

No coin nor oath required. For personal study only.

✦ Synopsis

Gastroparesis is a serious condition that limits meal or medication emptying from the stomach, resulting in a variety of symptoms, altered nutrition, and inconsistent medication delivery. Our aim was to develop a transmucosal system to deliver erythromycin (EM), a gastric prokinetic agent, to bypass intestinal absorption. Humans and Sprague-Dawley rats were given EM by injection, gavage, or transmucosal gel with or without permeation enhancers. Pharmacokinetics were compared between subjects and across different delivery modalities. Drug concentrations in blood were measured using a bioassay. Design of Experiment techniques were used to optimize transmucosal antibiotic delivery in the Sprague-Dawley Model. Finally, we examined the scale-up of transmucosal delivery to human patients. Transmucosal delivery of EM increased with addition of ursodeoxycholate. While EM release from gels with ursodeoxycholate was significant, it was less than by injection. Scale-up to a human model indicated that delivery of EM using this transmucosal delivery system is insufficient for clinical need. The transport of EM seems limited by its solubility in water and thickness of the epithelial cell layers. Providing successful transmucosal delivery of EM and similar molecules to humans will require more aggressive techniques to disrupt the cellular layer, or pro-drug strategies to increase lipid solubility.

📜 SIMILAR VOLUMES

Polymer–drug compatibility: A guide to t

Polymer–drug compatibility: A guide to the development of delivery systems for the anticancer agent, ellipticine

✍ Jubo Liu; Yuehua Xiao; Christine Allen 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB 👁 1 views

To establish a method for predicting polymer-drug compatibility as a means to guide formulation development, we carried out physicochemical analyses of polymer-drug pairs and compared the difference in total and partial solubility parameters of polymer and drug. For these studies, we employed a rang

Development of Drug Delivery System Base

Development of Drug Delivery System Based on a New Administration Route for Targeting to the Specific Region on the Liver

✍ Koyo Nishida 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 53 KB 👁 2 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

Repeatability of methacholine challenges

Repeatability of methacholine challenges in 2 to 4-year-old children with asthma, using a new technique for quantitative delivery of aerosol

✍ Bent Klug; Hans Bisgaard 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

To determine the repeatability of bronchial responsiveness in awake young children, two methacholine challenge tests were performed on separate days in 16 children with stable asthma (mean age, 3 3/4 years). Methacholine was administered using a new method for quantitative delivery of aerosol that e

Back to basics: The development of a sim

Back to basics: The development of a simple, homogenous, two-component dry-powder inhaler formulation for the delivery of budesonide using miscible vinyl polymers

✍ F. Buttini; P. Colombo; M.P.E. Wenger; P. Mesquida; C. Marriott; Stuart A. Jones 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB 👁 1 views

It was hypothesised that formulating a dry-powder inhaler (DPI) using a refined, smooth grade of lactose, without fines and a polymer coated drug microparticle should produce an homogeneous formulation in which aerosolisation behaviour could be modified. Hence, the aim of this study was to develop a

Development of a new hybrid technique fo

Development of a new hybrid technique for rapid speciation analysis by directly interfacing a microfluidic chip-based capillary electrophoresis system to atomic fluorescence spectrometry

✍ Feng Li; Dong-Dong Wang; Xiu-Ping Yan; Jin-Ming Lin; Rong-Guo Su 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB 👁 3 views

Development of a flow cytometric co-immu

Development of a flow cytometric co-immunoprecipitation technique for the study of multiple protein—protein interactions and its application to T-cell receptor analysis

✍ John S. Bridgeman; Morgan Blaylock; Robert E. Hawkins; David E. Gilham 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 707 KB

## Abstract Co‐immunoprecipitation is the classical approach for investigating protein–protein interactions. Analysis is generally conducted using the Western blot approach. We set out to investigate whether flow cytometry was a feasible alternative to Western blotting. Using the TCR‐CD3 complex as