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Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent

✍ Scribed by Seok-Rye Choi; Biao Yang; Karl Plössl; Sumalee Chumpradit; Shiaw-Pyng Wey; Paul D Acton; Kenneth Wheeler; Robert H Mach; Hank F Kung

Book ID
117687742
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
245 KB
Volume
28
Category
Article
ISSN
0969-8051

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The synthesis and in vitro binding of a novel 99m Tc-labeled radiotracer for imaging the sigma-2 (s 2 ) receptor status of breast tumors is described. Structural characterization and in vitro binding studies were conducted using the corresponding rhenium surrogate, Re-2. X-ray crystallographic studi