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Development of a tandem time-of-flight mass spectrometer with an electrospray ionization ion source

✍ Scribed by Hirofumi Nagao; Shuichi Shimma; Shigeo Hayakawa; Kunio Awazu; Michisato Toyoda

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
357 KB
Volume
45
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

A new tandem time‐of‐flight mass spectrometer with an electrospray ionization ion source ‘ESI‐TOF/quadTOF’ was designed and constructed to achieve the desired aim of structural elucidation via high‐energy collision‐induced dissociation (CID), and the simultaneous detection of all fragment ions. The instrument consists of an orthogonal acceleration‐type ESI ion source, a linear TOF mass spectrometer, a collision cell, a quadratic‐field ion mirror and a microchannel plate detector. High‐energy CID spectra of doubly protonated angiotensin II and bradykinin were obtained. Several fragment ions such as a‐, d‐, v‐ and w‐type ions, characteristic of high‐energy CID, were clearly observed in these spectra. These high‐energy CID fragment ions enabled confirmation of the complete sequence, including leucine–isoleucine determinations. It was demonstrated that high‐energy CID of multiply protonated peptides could be achieved in the ESI‐TOF/quadTOF. Copyright © 2010 John Wiley & Sons, Ltd.

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