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Development of a stability-indicating LC method for determination of a synthetic chalcone derivative in a nanoemulsion dosage form and identification of the main photodegradation product by LC–MS

✍ Scribed by Cristiane B. Mattos; Vânia B. Deponti; Fabiano Barreto; Cláudia M.O. Simões; Carla R. Andrighetti-Frohner; Ricardo J. Nunes; Mário Steindel; Helder F. Teixeira; Letícia S. Koester

Book ID
118477719
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
452 KB
Volume
70
Category
Article
ISSN
0731-7085

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## Abstract A stability‐indicating MEKC method was developed and validated for the analysis of lumiracoxib (LMC) in pharmaceutical formulations using nimesulide as the internal standard (IS). Optimal conditions for the separation of LMC and degradation products were investigated. The method employe