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Development of a sphingosine kinase 1 specific small-molecule inhibitor

✍ Scribed by Jeremy A. Hengst; XuJun Wang; Ugir H. Sk; Arun K. Sharma; Shantu Amin; Jong K. Yun

Book ID
104004977
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
295 KB
Volume
20
Category
Article
ISSN
0960-894X

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## Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) involved in the genesis of several human cancers; indeed, ALK was initially identified in constitutively activated and oncogenic fusion formsβ€”the most common being nucleophosmin (NPM)‐ALKβ€”in a non‐Hodgkin's lymphoma (N