✦ LIBER ✦

Development of a simple and selective separation of 67Cu from irradiated zinc for use in antibody labelling: A comparison of methods

✍ Scribed by Rolf Schwarzbach; Kurt Zimmermann; Peter Bläuenstein; Alan Smith; P. August Schubiger

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 761 KB
Volume: 46
Category: Article
ISSN: 0969-8043
DOI: 10.1016/0969-8043(95)00010-b

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✦ Synopsis

A procedure for the production and separation of Cu isotopes from irradiated Zn was developed. Following a comparison of methods based on extraction, electrolysis and ion-exchange chromatography, a technique for the separation of Cu employing three ion-exchange matrices was developed which was simple, reproducible and hot cell-compatible. The specific activity of the final product was 37 MBq 67Cu///g Cu at EOB. The level of impurities was so low that no interference with antibody labelling was observed.

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