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Development of a sequential linked pharmacokinetic and pharmacodynamic simulation model for ivabradine in healthy volunteers

✍ Scribed by Stephen B. Duffull; Leon Aarons


Book ID
114301735
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
278 KB
Volume
10
Category
Article
ISSN
0928-0987

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## Background Interferon (IFN) alpha conjugation to polyethylene glycol (PEG) results in a better pharmacokinetic profile and efficacy. The aim of this study was to compare the pharmacokinetic, pharmacodynamic and safety properties of a new, locally developed, 40-kDa PEG-IFN alpha-2b preparation wi