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Development of a sensitive LC-MS/MS method for simultaneous quantification of eleven constituents in rat serum and its application to a pharmacokinetic study of a Chinese medicine Shengmai injection

✍ Scribed by Zhan, Shuyu; Shao, Qing; Fan, Xiaohui; Li, Zheng

Book ID
127255855
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
796 KB
Volume
29
Category
Article
ISSN
0269-3879

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## ABSTRACT A highly sensitive and specific LC‐MS/MS‐ESI method was developed for simultaneous quantification of albenadazole (ABZ) and ricobendazole (RBZ) in rat plasma (50 μL) using phenacetin as an internal standard (IS). Simple protein precipitation was used to extract ABZ and RBZ from rat plas