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Development of a Rhenium-186-Labeled MAG3-Conjugated Bisphosphonate for the Palliation of Metastatic Bone Pain Based on the Concept of Bifunctional Radiopharmaceuticals

✍ Scribed by Ogawa, Kazuma; Mukai, Takahiro; Arano, Yasushi; Ono, Masahiro; Hanaoka, Hirofumi; Ishino, Seigo; Hashimoto, Kazuyuki; Nishimura, Hiroshi; Saji, Hideo


Book ID
118042333
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
109 KB
Volume
16
Category
Article
ISSN
1043-1802

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Design of a radiopharmaceutical for the
✍ Kazuma Ogawa; Takahiro Mukai; Yasushi Arano; Hirofumi Hanaoka; Kazuyuki Hashimot 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 123 KB

## Abstract To develop a radiopharmaceutical for the palliation of painful bone metastases based on the concept of bifunctional radiopharmaceuticals, we designed a bisphosphonate derivative attached to a stable ^186^Re‐monoaminemonoamidedithiol (MAMA) chelate (^186^Re‐MAMA‐BP) to improve the instab