Physiologically based pharmacokinetic (PBPK) models were developed for design and optimization of liposome therapy for treatment of overdoses of tricyclic antidepressants and local anesthetics. In vitro drug-binding data for pegylated, anionic liposomes and published mechanistic equations for partit
Development of a Physiology-Based Whole-Body Population Model for Assessing the Influence of Individual Variability on the Pharmacokinetics of Drugs
✍ Scribed by Stefan Willmann; Karsten Höhn; Andrea Edginton; Michael Sevestre; Juri Solodenko; Wolfgang Weiss; Jörg Lippert; Walter Schmitt
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 555 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1573-8744
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