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Development of a novel self-dissolving microneedle array of alendronate, a nitrogen-containing bisphosphonate: Evaluation of transdermal absorption, safety, and pharmacological effects after application in rats

โœ Scribed by Katsumi, Hidemasa (author);Liu, Shu (author);Tanaka, Yutaro (author);Hitomi, Kaori (author);Hayashi, Rie (author);Hirai, Yuka (author);Kusamori, Kosuke (author);Quan, Ying Shu (author);Kamiyama, Fumio (author);Sakane, Toshiyasu (author);Yamamoto, Akira (author)


Book ID
112134540
Publisher
John Wiley and Sons Inc.
Year
2012
Tongue
English
Weight
360 KB
Volume
101
Category
Article
ISSN
0022-3549

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Bisphosphonates are widely used for the treatment of bone diseases, including hypercalcemia and osteoporosis. However, the bioavailability (BA) of orally administered bisphosphonates is low, at approximately 0.9%-1.8%. In addition, the oral administration of bisphosphonates is associated with mucosa