Development of a novel histone H1-based recombinant fusion peptide for targeted non-viral gene delivery

A powerful cooperative interaction betwe

A powerful cooperative interaction between a fusogenic peptide and lipofectamine for the enhancement of receptor-targeted, non-viral gene delivery via integrin receptors

✍ Xiaohong Zhang; Louise Collins; John W. Fabre 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 135 KB 👁 1 views

Background Following receptor-mediated endocytosis, vector/DNA complexes require assistance to exit endocytic vesicles in order to avoid degradation in the lysosomes. Overcoming this barrier is a major challenge for the development of receptor-targeted, non-viral gene delivery. ## Methods The fus