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Development of a murine gastric distension model for testing the emetic potential of new drugs and efficacy of antiemetics

✍ Scribed by Ian N. Olver; Ian A.G. Roos; Kim Thomas; Brian L. Hillcoat


Book ID
113137273
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
277 KB
Volume
69
Category
Article
ISSN
0009-2797

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## Abstract Analytical HPLC methods using derivatized cellulose and amylose chiral stationary phases used in normal and reversed‐phase modes were developed for the diastereoisomeric separation of mononucleotide prodrugs (pronucleotides) of 3′‐azido‐2β€²,3′‐dideoxythymidine (AZT). The resolutions were