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Development of a microwave-enhanced isotopic labelling procedure based on the Eschweiler–Clarke methylation reaction

✍ Scribed by John R. Harding; John R. Jones; Shui-Yu Lu; Robin Wood


Book ID
104252576
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
123 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis


A number of primary and secondary amines have been rapidly methylated under microwave-enhanced conditions using formic acid-formaldehyde mixtures, providing a route to 2 H(D)-containing compounds and the potential for 3 H(T), 11 C, 13 C and 14 C labelling.