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Development of a High-Throughput Screen and Its Use in the Discovery of Streptococcus pneumoniae Immunoglobulin A1 Protease Inhibitors

✍ Scribed by Garner, Amanda L.; Fullagar, Jessica L.; Day, Joshua A.; Cohen, Seth M.; Janda, Kim D.


Book ID
120498503
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
658 KB
Volume
135
Category
Article
ISSN
0002-7863

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The program DOCK [1,2] has been used successfully to identify molecules which will bind to a specified receptor [3]. The original method ranks molecules based on their shape complementarity to the receptor site and relies on the chemist to bring the appropriate electrostatic or hydrogen bond propert