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Development of a GC-MS method for quantitation of 2, 3-dinor-TXB2 and determinations of the daily urinary excretion rates in healthy humans

✍ Scribed by Ole Vesterqvist; Krister Gréen; Frank H. Lincoln; Oldrich K. Sebek

Book ID
119035405
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
707 KB
Volume
33
Category
Article
ISSN
0049-3848

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## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i