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Development of a Fluorescent Occupancy Assay for the NK-1R Tachykinin Receptor

✍ Scribed by ORANGE, J; DOUGLAS, S; TULUC, F; SHAWVER, L

Book ID
119280314
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
44 KB
Volume
121
Category
Article
ISSN
1097-6825

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The development of a novel series of non
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In this paper we describe the transformation of a series of modified dipeptide NK 3 receptor selective ligands, previously developed from a hit identified from the screening of a dipeptide chemical library, into non-peptide, nanomolar affinity NK 3 receptor selective antagonists eg. PD160946 and PD1