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Development of a capillary gel electrophoresis method for monitoring disulfide isomer heterogeneity in IgG2 antibodies

✍ Scribed by Nathan A. Lacher; Qian Wang; Rachel K. Roberts; Heidi J. Holovics; Serdar Aykent; Michael R. Schlittler; Melissa R. Thompson; Charles W. Demarest


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
419 KB
Volume
31
Category
Article
ISSN
0173-0835

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## Abstract Capillary gel electrophoresis (CGE) methods with UV detection were developed for reduced and non‐reduced mAb analysis. These methods can be used to evaluate mAb purity, offering more reproducible quantitation compared with that of traditional SDS‐PAGE methods. These CGE methods have bee