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Development of [90Y]DOTA-conjugated bisphosphonate for treatment of painful bone metastases

✍ Scribed by Kazuma Ogawa; Hidekazu Kawashima; Kazuhiro Shiba; Kohshin Washiyama; Mitsuyoshi Yoshimoto; Yasushi Kiyono; Masashi Ueda; Hirofumi Mori; Hideo Saji


Book ID
116799286
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
178 KB
Volume
36
Category
Article
ISSN
0969-8051

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## Abstract To develop a radiopharmaceutical for the palliation of painful bone metastases based on the concept of bifunctional radiopharmaceuticals, we designed a bisphosphonate derivative attached to a stable ^186^Re‐monoaminemonoamidedithiol (MAMA) chelate (^186^Re‐MAMA‐BP) to improve the instab