✦ LIBER ✦

Development of 5-(aminomethyl)pyrrole-2-carboxylic acid as a constrained surrogate of Gly-ΔAla and its application in peptidomimetic studies

✍ Scribed by Tushar K Chakraborty; B Krishna Mohan; S Kiran Kumar; Ajit C Kunwar

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 90 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00342-8

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✦ Synopsis

A new peptidomimetic scaffold based on 5-(aminomethyl)pyrrole-2-carboxylic acid (1) is developed for the first time and used as a conformationally constrained surrogate of the Gly-DAla dipeptide isostere (2) to prepare peptides 3 and 4.