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Development, characterization and application of in situ gel systems for intranasal delivery of tacrine

โœ Scribed by Qian, Shuai; Wong, Yin Cheong; Zuo, Zhong

Book ID
121663183
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
732 KB
Volume
468
Category
Article
ISSN
0378-5173

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โœ Park, Jeong-Sook ;Oh, Yu-Kyoung ;Yoon, Ho ;Kim, Jung Mogg ;Kim, Chong-Kook ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 682 KB

## Abstract Nasal administration of plasmid DNA is emerging as a new route of delivery for therapeutic genes and DNA vaccines. To improve the intranasal absorption of plasmid DNA, we designed delivery systems composed of __in situ__ gelling and mucoadhesive polymers. Poloxamers (Pol) were used to p