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Development and validation of a reversed-phase liquid chromatographic method for analysis of aspirin and warfarin in a combination tablet formulation

✍ Scribed by Eda Ross Montgomery; Suzanne Taylor; James Segretario; Elizabeth Engler; Dolores Sebastian

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
684 KB
Volume
15
Category
Article
ISSN
0731-7085

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✦ Synopsis

A stability-indicating liquid chromatographic method for the simultaneous analysis of aspirin and warfarin in warfarin sodium/aspirin combination (DuP 647) tablets has been developed and validated. This paper presents linearity, accuracy, precision, robustness, recovery, limits of detection and quantitation, and cross-validation data. The method has been shown to be specific and stability-indicating, and to give results comparable to existing methods for the individual components. Solution stability has been optimized for routine analysis.

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