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Development and validation of a rapid LC-ESI-MS/MS method for quantification of fluoxetine and its application to MS binding assays

✍ Scribed by Marielle Hess; Georg Höfner; Klaus Theodor Wanner


Publisher
Springer
Year
2011
Tongue
English
Weight
286 KB
Volume
400
Category
Article
ISSN
1618-2650

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An analytical method based on liquid–liquid extraction has been developed and validated for analysis of agomelatine in human plasma. Fluoxetine was used as an internal standard for agomelatine. A Betasil C18 (4.0 × 100 mm, 5 µm) column provided chromatographic separation of analytes followed by dete