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Development and validation of a rapid capillary zone electrophoresis method for determining charge variants of mAb

✍ Scribed by Ying Shi; Zhen Li; Yuanbiao Qiao; Jun Lin

Book ID: 119289271
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 552 KB
Volume: 906
Category: Article
ISSN: 1873-376X
DOI: 10.1016/j.jchromb.2012.08.022

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## Abstract A capillary zone electrophoresis (CZE) method was developed for the rapid analysis of charge heterogeneity of immunoglobulin G (IgG) monoclonal antibodies (mAbs). The separation was carried out in a short, dynamically coated fused‐silica capillary. A number of separation parameters were